Make a Messe of it...
The hotel is very popular with guests in town for one of Frankfurt's famous trade fairs, as the Messe is within a comfortable walking distance, under ten minutes for most. The S-Bahn is right there also, and will get sightseers to the city centre in about 15 minutes. There is also a tram stop just a few steps out the hotel entrance, and guests note there are always taxis waiting there, too. The Seckennberg Natural History Museum is within walking distance.